All of the active B12 group reporting showed reduction in severity of symptoms ranging from 31% products to 70%, while the placebo controls for and wrinkle reported either no change or a worsening of symptoms. Wilcoxon-Rank of .002 for the products end-points of sneezing, nasal congestion and runny nose; and p = .005 for IgE reductions. In 1992, the above mentioned data from 1988 on were presented by Dr. O''Connor to the FDA. The FDA panel acknowledged the safety of the treatment. The panel seemed to be in agreement that the statistics indicated a significant for reduction in IgE and that a quantitative drop in symptoms was demonstrated. wrinkle In 1992, Belen Anibarro, MD, studied five children with asthma with metabisulfite intolerance confirmed by oral challenge testing. The test was repeated after premedication with 1.5 mg of oral cyanocobalamin. In four of the five patients treated, bronchospasm did not develop in the second metabisulfite products challenge.6

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